Cat.No. KIT 043

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Cat. No.
KIT 043
Product name
A quantitative assay for  the in vitro determination of dog NGAL in urine, plasma, serum, tissue extracts or culture media.
Assay range
4-400 pg/mL
Assay time
<4 hours
Limit of detection
0.56 pg/mL
Species reactivity (positive)
Dog NGAL (Neutrophil Gelatinase-Associated Lipocalin)
NGAL determination allows kidney injury to be detected almost as soon as it occurs, and not at the later stage when the consequences of impaired kidney function can be detected by existing routine tests and the damage has been consolidated.
Dogs provide additional information in the study of kidney function, surgical procedures and treatment in relation to human disease, and canine studies continue to be important in drug development. The dog NGAL ELISA test is non-invasive, and gives an early indication of kidney damage, uses little sample and is easy to perform. NGAL measurement in dogs may prove to be of considerable value in the preclinical evaluation of new pharmaceutical products, as it is much cheaper and easier to perform than microscopic examination of the kidney, which has hitherto been the usual procedure.
The test can potentially be used to measure drug efficacy in the development of new treatments for kidney damage, to assess safety or nephrotoxic side effects of new drugs, and can be used in basic research on kidney injury and kidney diseases, e.g. in the folowing settings:
Research and development
Pre-clinical phase
Regulatory status
RUO - Research Use Only.
Other information
Kit features Highly reproducible and easy to use Ready-to-use working solutions Ready-to-use calibrators Pre-coated 96-well ELISA plate All incubations performed at room temperature Easy storage All components are stored at 4°C Requires only standard ELISA equipment
Ahn HJ, Hyun C (2013) Evaluation of serum neutrophil gelatinase-associated lipocalin (NGAL) activity in dogs with chronic kidney disease. Vet Rec. 173:452
Daure E, Belanger MC, Beauchamp G, Lapointe C (2013) Elevation of neutrophil gelatinase-associated lipocalin (NGAL) in non-azotemic dogs with urinary tract infection. Res Vet Sci. 95:1181-1185
Kai K, Yamaguchi T, Yoshimatsu Y, Kinoshita J, Teranishi M, Takasaki W (2013) Neutrophil gelatinase-associated lipocalin, a sensitive urinary biomarker of acute kidney injury in dogs receiving gentamicin. J Toxicol Sci. 38:269-277
Segev G, Bankirer T, Steinberg D, Duvdevani M, Shapur NK, Friedman M, Lavy E (2013) Evaluation of urinary catheters coated with sustained-release varnish of chlorhexidine in mitigating biofilm formation on urinary catheters in dogs. J Vet Intern Med. 27:39-46
Nabity MB, Lees GE, Cianciolo R, Boggess MM, Steiner JM, Suchodolski JS (2012) Urinary biomarkers of renal disease in dogs with X-linked hereditary nephropathy. J Vet Intern Med. 26:282-293